DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems.

ABSTRACT: Dye-ing to live: Spectral limitations of common organic dyes make it difficult or impossible to visualize and follow multiple biological components in rapidly moving systems. The development of a multispectral set of improved DNA-scaffolded fluorophores is described. Their use in multicolor cellular imaging (see scheme) and in tracking of biological motions on the subsecond timescale is demonstrated.

SUBMITTER: Wang S 

PROVIDER: S-EPMC3489938 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature