Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study.

ABSTRACT:

Background

Three subtypes of Alzheimer's disease (AD) have been pathologically defined on the basis of the distribution of neurofibrillary tangles: typical AD, hippocampal-sparing AD, and limbic-predominant AD. Compared with typical AD, hippocampal-sparing AD has more neurofibrillary tangles in the cortex and fewer in the hippocampus, whereas the opposite pattern is seen in limbic-predominant AD. We aimed to determine whether MRI patterns of atrophy differ between these subtypes and whether structural neuroimaging could be a useful predictor of pathological subtype at autopsy.

Methods

We identified patients who had been followed up in the Mayo Clinic Alzheimer's Disease Research Center (Rochester, MN, USA) or in the Alzheimer's Disease Patient Registry (Rochester, MN, USA) b

SUBMITTER: Whitwell JL 

PROVIDER: S-EPMC3490201 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature