Characterization of genomic regulatory domains conserved across the genus Drosophila.

ABSTRACT: In both vertebrates and insects, the conservation of local gene order among distantly related species (microsynteny) is higher than expected in the presence of highly conserved noncoding elements (HCNEs). Dense clusters of HCNEs, or HCNE peaks, have been proposed to mediate the regulation of sometimes distantly located genes, which are central for the developmental program of the organism. Thus, the regions encompassing HCNE peaks and their targets in different species would form genomic regulatory domains (GRDs), which should presumably enjoy an enhanced stability over evolutionary time. By leveraging genome rearrangement information from nine Drosophila species and using gene functional and phenotypic information, we performed a comprehensive characterization of the organization of micro

SUBMITTER: Sahagun V 

PROVIDER: S-EPMC3490413 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature