Palladium-catalyzed annulation of arynes by o-halobenzamides: synthesis of phenanthridinones.

ABSTRACT: The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N-substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C-C and C-N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups.

SUBMITTER: Lu C 

PROVIDER: S-EPMC3490708 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature