In silico evolutionary analysis of Helicobacter pylori outer membrane phospholipase A (OMPLA).

ABSTRACT:

Background

In the past decade, researchers have proposed that the pldA gene for outer membrane phospholipase A (OMPLA) is important for bacterial colonization of the human gastric ventricle. Several conserved Helicobacter pylori genes have distinct genotypes in different parts of the world, biogeographic patterns that can be analyzed through phylogenetic trees. The current study will shed light on the importance of the pldA gene in H. pylori. In silico sequence analysis will be used to investigate whether the bacteria are in the process of preserving, optimizing, or rejecting the pldA gene. The pldA gene will be phylogenetically compared to other housekeeping (HK) genes, and a possible origin via horizontal gene transfer (HGT) will be evaluated through both intra- and inter-species

SUBMITTER: Vollan HS 

PROVIDER: S-EPMC3490997 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature