Classification of human genomic regions based on experimentally determined binding sites of more than 100 transcription-related factors.

ABSTRACT:

Background

Transcription factors function by binding different classes of regulatory elements. The Encyclopedia of DNA Elements (ENCODE) project has recently produced binding data for more than 100 transcription factors from about 500 ChIP-seq experiments in multiple cell types. While this large amount of data creates a valuable resource, it is nonetheless overwhelmingly complex and simultaneously incomplete since it covers only a small fraction of all human transcription factors.

Results

As part of the consortium effort in providing a concise abstraction of the data for facilitating various types of downstream analyses, we constructed statistical models that capture the genomic features of three paired types of regions by machine-learning methods: firstly, regions with acti

SUBMITTER: Yip KY 

PROVIDER: S-EPMC3491392 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature