Modeling gene expression using chromatin features in various cellular contexts.

ABSTRACT:

Background

Previous work has demonstrated that chromatin feature levels correlate with gene expression. The ENCODE project enables us to further explore this relationship using an unprecedented volume of data. Expression levels from more than 100,000 promoters were measured using a variety of high-throughput techniques applied to RNA extracted by different protocols from different cellular compartments of several human cell lines. ENCODE also generated the genome-wide mapping of eleven histone marks, one histone variant, and DNase I hypersensitivity sites in seven cell lines.

Results

We built a novel quantitative model to study the relationship between chromatin features and expression levels. Our study not only confirms that the general relationships found in previous studi

SUBMITTER: Dong X 

PROVIDER: S-EPMC3491397 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature