Epigenetic transgenerational inheritance of somatic transcriptomes and epigenetic control regions.

ABSTRACT:

Background

Environmentally induced epigenetic transgenerational inheritance of adult onset disease involves a variety of phenotypic changes, suggesting a general alteration in genome activity.

Results

Investigation of different tissue transcriptomes in male and female F3 generation vinclozolin versus control lineage rats demonstrated all tissues examined had transgenerational transcriptomes. The microarrays from 11 different tissues were compared with a gene bionetwork analysis. Although each tissue transgenerational transcriptome was unique, common cellular pathways and processes were identified between the tissues. A cluster analysis identified gene modules with coordinated gene expression and each had unique gene networks regulating tissue-specific gene expression and fun

SUBMITTER: Skinner MK 

PROVIDER: S-EPMC3491419 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature