Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response.

ABSTRACT: The hippocampus is a highly plastic brain region particularly susceptible to the effects of environmental stress; it also shows dynamic changes in epigenetic marks in response to stress and learning. We have previously shown that, in the rat, acute (30 min) restraint stress induces a substantial, regionally specific, increase in hippocampal levels of the repressive histone H3 lysine 9 trimethylation (H3K9me3). Because of the large magnitude of this effect and the fact that stress can induce the expression of endogenous retroviruses and transposable elements in many systems, we hypothesized that the H3K9me3 response was targeted to these elements as a means of containing potential genomic instability. We used ChIP coupled with next generation sequencing (ChIP-Seq) to determine the genomic l

SUBMITTER: Hunter RG 

PROVIDER: S-EPMC3491472 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature