Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey.

ABSTRACT: Widespread use of the endocrine disrupting chemical bisphenol A (BPA) in consumer products has resulted in nearly continuous human exposure. In rodents, low-dose exposures have been reported to adversely affect two distinct stages of oogenesis in the developing ovary: the events of prophase at the onset of meiosis in the fetal ovary and the formation of follicles in the perinatal ovary. Because these effects could influence the reproductive longevity and success of the exposed individual, we conducted studies in the rhesus monkey to determine whether BPA induces similar disturbances in the developing primate ovary. The routes and levels of human exposure are unclear; hence, two different exposure protocols were used: single daily oral doses and continuous exposure via subdermal implant. Ou

SUBMITTER: Hunt PA 

PROVIDER: S-EPMC3491481 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature