Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C.

ABSTRACT:

Aim

To construct formulae for predicting the likelihood of ribavirin-induced anemia in pegylated interferon α plus ribavirin for chronic hepatitis C.

Methods

Five hundred and sixty-one Japanese patients with hepatitis C virus genotype 1b who had received combination treatment were enrolled and assigned randomly to the derivation and confirmatory groups. Single nucleotide polymorphisms at or nearby ITPA were genotyped by real-time detection polymerase chain reaction. Factors influencing significant anemia (hemoglobin concentration < 10.0 g/dL at week 4 of treatment) and significant hemoglobin decline (declining concentrations > 3.0 g/dL at week 4) were analyzed using multiple regression analyses. Prediction formulae were constructed by significantly independent factors.

Re

SUBMITTER: Tsubota A 

PROVIDER: S-EPMC3491594 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature