Severe outcomes are associated with genogroup 2 genotype 4 norovirus outbreaks: a systematic literature review.

ABSTRACT:

Background

Noroviruses (NoVs) are the most common cause of epidemic gastroenteritis; however, the relative impacts of individual factors underlying severe illness are poorly understood. This report reviews published NoV outbreak reports to quantify hospitalization and mortality rates and assess their relationship with outbreak setting, transmission route, and strain.

Methods

Using a string of terms related to "norovirus" and "outbreak," we 2435 nonduplicate articles identified in PubMed, EMBASE, and Web of Knowledge published between January 1993 and June 2011. Inclusion criteria included outbreaks with a minimum of 2 ill persons with a common exposure and at least 1 reverse-transcription polymerase chain reaction-confirmed case of NoV disease. Univariate analyses were perfo

SUBMITTER: Desai R 

PROVIDER: S-EPMC3491774 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature