Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections.

ABSTRACT:

Background

Intra-abdominal infections are common in young infants and lead to significant morbidity and mortality. Meropenem is a broad-spectrum antimicrobial with excellent activity against pathogens associated with intra-abdominal infections. The purpose of this study was to determine the safety and effectiveness of meropenem in young infants with suspected or complicated intra-abdominal infections.

Methods

Preterm and term infants <91 days of age with suspected or confirmed intra-abdominal infections hospitalized in 24 neonatal intensive care units were studied in an open-label, multiple-dose study. Adverse events and serious adverse events were collected through 3 and 30 days following the last meropenem dose, respectively. Effectiveness was assessed by 3 criteria: death

SUBMITTER: Cohen-Wolkowiez M 

PROVIDER: S-EPMC3491861 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature