T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion.

ABSTRACT: The evolution of immune blockades in tumors limits successful antitumor immunity, but the mechanisms underlying this process are not fully understood. Depletion of regulatory T cells (Treg), a T-cell subset that dampens excessive inflammatory and autoreactive responses, can allow activation of tumor-specific T cells. However, cancer immunotherapy studies have shown that a persistent failure of activated lymphocytes to infiltrate tumors remains a fundamental problem. In evaluating this issue, we found that despite an increase in T-cell activation and proliferation following Treg depletion, there was no significant association with tumor growth rate. In contrast, there was a highly significant association between low tumor growth rate and the extent of T-cell infiltration. Further analyses r

SUBMITTER: Hindley JP 

PROVIDER: S-EPMC3491872 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature