Prognostic indicators of life-threatening malaria are associated with distinct parasite variant antigen profiles.

ABSTRACT: PfEMP1 is a family of cytoadhesive surface antigens expressed on erythrocytes infected with Plasmodium falciparum, the parasite that causes the most severe form of malaria. These surface antigens play a role in immune evasion and are thought to contribute to the pathogenesis of the malaria parasite. Previous studies have suggested a role for a specific subset of PfEMP1 called "group A" in severe malaria. To explore the role of group A PfEMP1 in disease, we measured the expression of the var genes that encode them in parasites from clinical isolates collected from children suffering from malaria. We also looked at the ability of these clinical isolates to induce rosetting of erythrocytes, which indicates a cytoadhesion phenotype that is thought to be important in pathogenesis. These two set

SUBMITTER: Warimwe GM 

PROVIDER: S-EPMC3491874 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature