Parameterizing dose-response models to estimate relative potency functions directly.

ABSTRACT: Many comparative analyses of toxicity assume that the potency of a test chemical relative to a reference chemical is constant, but employing such a restrictive assumption uncritically may generate misleading conclusions. Recent efforts to characterize non-constant relative potency rely on relative potency functions and estimate them secondarily after fitting dose-response models for the test and reference chemicals. We study an alternative approach of specifying a relative potency model a priori and estimating it directly using the dose-response data from both chemicals. We consider a power function in dose as a relative potency model and find that it keeps the two chemicals' dose-response functions within the same family of models for families typically used in toxicology. When difference

SUBMITTER: Dinse GE 

PROVIDER: S-EPMC3491959 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature