A meta-analysis and multisite time-series analysis of the differential toxicity of major fine particulate matter constituents.

ABSTRACT: Health risk assessments of particulate matter less than 2.5 μm in diameter (PM(2.5)) often assume that all constituents of PM(2.5) are equally toxic. While investigators in previous epidemiologic studies have evaluated health risks from various PM(2.5) constituents, few have conducted the analyses needed to directly inform risk assessments. In this study, the authors performed a literature review and conducted a multisite time-series analysis of hospital admissions and exposure to PM(2.5) constituents (elemental carbon, organic carbon matter, sulfate, and nitrate) in a population of 12 million US Medicare enrollees for the period 2000-2008. The literature review illustrated a general lack of multiconstituent models or insight about probabilities of differential impacts per unit of concentr

SUBMITTER: Levy JI 

PROVIDER: S-EPMC3491972 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature