Identification of serum proteomic biomarkers for early porcine reproductive and respiratory syndrome (PRRS) infection.

ABSTRACT:

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Background

Porcine reproductive and respiratory syndrome (PRRS) is one of the most significant swine diseases worldwide. Despite its relevance, serum biomarkers associated with early-onset viral infection, when clinical signs are not detectable and the disease is characterized by a weak anti-viral response and persistent infection, have not yet been identified. Surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOF MS) is a reproducible, accurate, and simple method for the identification of biomarker proteins related to disease in serum. This work describes the SELDI-TOF MS analyses of sera of 60 PRRSV-positive and 60 PRRSV-negative, as measured by PCR, asymptomatic Large White piglets at weaning. Sera with comparable and low con

SUBMITTER: Genini S 

PROVIDER: S-EPMC3492009 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature