Huntington's disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database.

ABSTRACT:

Background

Huntington's disease (HD) is a fatal progressive neurodegenerative disorder caused by the expansion of the polyglutamine repeat region in the huntingtin gene. Although the disease is triggered by the mutation of a single gene, intensive research has linked numerous other genes to its pathogenesis. To obtain a systematic overview of these genes, which may serve as therapeutic targets, CHDI Foundation has recently established the HD Research Crossroads database. With currently over 800 cataloged genes, this web-based resource constitutes the most extensive curation of genes relevant to HD. It provides us with an unprecedented opportunity to survey molecular mechanisms involved in HD in a holistic manner.

Methods

To gain a synoptic view of therapeutic targets for HD,

SUBMITTER: Kalathur RK 

PROVIDER: S-EPMC3492045 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature