Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer.

ABSTRACT:

Background

Podocalyxin-like 1 (PODXL) is a cell-adhesion glycoprotein and stem cell marker that has been associated with an aggressive tumour phenotype and adverse outcome in several cancer types. We recently demonstrated that overexpression of PODXL is an independent factor of poor prognosis in colorectal cancer (CRC). The aim of this study was to validate these results in two additional independent patient cohorts and to examine the correlation between PODXL mRNA and protein levels in a subset of tumours.

Method

PODXL protein expression was analyzed by immunohistochemistry in tissue microarrays with tumour samples from a consecutive, retrospective cohort of 270 CRC patients (cohort 1) and a prospective cohort of 337 CRC patients (cohort 2). The expression of PODXL mRNA was

SUBMITTER: Larsson A 

PROVIDER: S-EPMC3492217 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature