Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips.

ABSTRACT: Tauopathies including Alzheimer's disease represent one of the major health problems of aging population worldwide. Therefore, a better understanding of tau-dependent pathologies and consequently, tau-related intervention strategies is highly demanded. In recent years, several tau-focused therapies have been proposed with the aim to stop disease progression. However, to develop efficient active pharmaceutical ingredients for the broad treatment of Alzheimer's disease patients, further improvements are necessary for understanding the detailed neurodegenerative processes as well as the mechanism and side effects of potential active pharmaceutical ingredients (API) in the neuronal system. In this context, there is a lack of suitable complex in vitro cell culture models recapitulating major as

SUBMITTER: Seidel D 

PROVIDER: S-EPMC3492324 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature