Ontology highlight
ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC3492362 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
He Yongzheng Y Rhodes Steven D SD Chen Shi S Wu Xiaohua X Yuan Jin J Yang Xianlin X Jiang Li L Li Xianqi X Takahashi Naoyuki N Xu Mingjiang M Mohammad Khalid S KS Guise Theresa A TA Yang Feng-Chun FC
PloS one 20121107 11
Skeletal abnormalities including osteoporosis and osteopenia occur frequently in both pediatric and adult neurofibromatosis type 1 (NF1) patients. NF1 (Nf1) haploinsufficient osteoclasts and osteoclast progenitors derived from both NF1 patients and Nf1(+/-) mice exhibit increased differentiation, migration, and bone resorptive capacity in vitro, mediated by hyperactivation of p21(Ras) in response to limiting concentrations of macrophage-colony stimulating factor (M-CSF). Here, we show that M-CSF ...[more]