Ranking transitive chemical-disease inferences using local network topology in the comparative toxicogenomics database.

ABSTRACT: Exposure to chemicals in the environment is believed to play a critical role in the etiology of many human diseases. To enhance understanding about environmental effects on human health, the Comparative Toxicogenomics Database (CTD; http://ctdbase.org) provides unique curated data that enable development of novel hypotheses about the relationships between chemicals and diseases. CTD biocurators read the literature and curate direct relationships between chemicals-genes, genes-diseases, and chemicals-diseases. These direct relationships are then computationally integrated to create additional inferred relationships; for example, a direct chemical-gene statement can be combined with a direct gene-disease statement to generate a chemical-disease inference (inferred via the shared gene). In CT

SUBMITTER: King BL 

PROVIDER: S-EPMC3492369 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature