The relative influences of phosphometabolites and pH on action potential morphology during myocardial reperfusion: a simulation study.

ABSTRACT: Myocardial ischemia-reperfusion (IR) injury represents a constellation of pathological processes that occur when ischemic myocardium experiences a restoration of perfusion. Reentrant arrhythmias, which represent a particularly lethal manifestation of IR injury, can result when ischemic tissue exhibits decreased excitability and/or changes of action potential duration (APD), conditions that precipitate unidirectional conduction block. Many of the cellular components that are involved with IR injury are modulated by pH and/or phosphometabolites such as ATP and phosphocreatine (PCr), all of which can be manipulated in vivo and potentially in the clinical setting. Using a mathematical model of the cardiomyocyte that we previously developed to study ischemia and reperfusion, we performed a seri

SUBMITTER: Roberts BN 

PROVIDER: S-EPMC3492384 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature