Safety of atomoxetine in combination with intravenous cocaine in cocaine-experienced participants.

ABSTRACT:

Objectives

Atomoxetine has been considered as an agonist replacement therapy for cocaine. We investigated the safety of the interaction of atomoxetine with cocaine and also whether cognitive function was affected by atomoxetine during short-term administration.

Methods

In a double-blind placebo-controlled inpatient study of 20 cocaine-dependent volunteers, participants received atomoxetine 80 mg daily followed by 100 mg daily for 5 days each. On the fourth and fifth day at each dose, cocaine (20 and 40 mg) was infused intravenously in sequential daily sessions.

Results

Preinfusion mean systolic pressures showed a small but statistically significant difference between placebo and both doses of atomoxetine. Preinfusion mean diastolic pressures were significant between p

SUBMITTER: Cantilena L 

PROVIDER: S-EPMC3492533 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature