Phylogenetic analysis of HDV isolates from HBsAg positive patients in Karachi, Pakistan.

ABSTRACT:

Background

In spite of a high occurrence of Hepatitis Delta in the province of Sindh in Pakistan, no genetic study of Hepatitis Delta virus (HDV) isolates from this region was carried out. The aim of this study is to analyze the genetic proximity within local HDV strains, and relationship with other clades of HDV, using phylogenetic analysis.

Results

Phylogenetic analysis of nucleotide sequences of the Hepatitis Delta Antigen (HDAg) R0 region obtained in this study, showed considerable diversity among the local strains with a potential subgroup formation within clade I. The multiple sequence alignment of predicted amino acids within clade I showed many uncommon amino acid substitutions within some conserved regions that are crucial for replication and assembly of HDV.

Con

SUBMITTER: Perveen S 

PROVIDER: S-EPMC3493343 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature