Human macrophage response to L. (Viannia) panamensis: microarray evidence for an early inflammatory response.

ABSTRACT:

Background

Previous findings indicate that susceptibility to Leishmania (Viannia) panamensis infection of monocyte-derived macrophages from patients and asymptomatically infected individuals were associated with the adaptive immune response and clinical outcome.

Methodology/principal findings

To understand the basis for this difference we examined differential gene expression of human monocyte-derived macrophages following exposure to L. (V.) panamensis. Gene activation profiles were determined using macrophages from healthy volunteers cultured with or without stationary phase promastigotes of L. (V.) panamensis. Significant changes in expression (>1.5-fold change; p<0.05; up- or down-regulated) were identified at 0.5, 4 and 24 hours. mRNA abundance profiles varied over time

SUBMITTER: Ramirez C 

PROVIDER: S-EPMC3493378 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature