Reporting of preclinical tumor-graft cancer therapeutic studies.

ABSTRACT:

Purpose

Characterize the parameters of reporting tumor-graft experiments for oncologic drug development.

Experimental design

Using Institute of Scientific Information impact factors, we identified the most-cited medical and oncology journals with tumor-graft experiments in murine models. For each article, the characteristics of the experimental design, outcome measurements, and statistical analysis were examined.

Results

We examined 145 articles describing tumor-graft experiments from October through December 2008. The articles spanned a range of disease types, animal models, treatments and delivery methods. One hundred (69%) articles were missing information needed to replicate the experiments. Outcome measurements included: tumor size (83%), biological changes (57%)

SUBMITTER: Sugar E 

PROVIDER: S-EPMC3493433 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature