Bioinformatic analysis of epigenetic and microRNA mediated regulation of drought responsive genes in rice.

ABSTRACT: Drought stress response is a complex trait regulated at multiple levels. Changes in the epigenetic and miRNA regulatory landscape can dramatically alter the outcome of a stress response. However, little is known about the scope and extent of these regulatory factors on drought related cellular processes and functions. To this end, we selected a list of 5468 drought responsive genes (DRGs) of rice identified in multiple microarray studies and mapped the DNA methylation regions found in a genome wide methylcytosine immunoprecipitation and sequencing (mCIP-Seq) study to their genic and promoter regions, identified the chromatin remodeling genes and the genes that are targets of miRNAs. We found statistically significant enrichment of DNA methylation reads and miRNA target sequences in DRGs co

SUBMITTER: Shaik R 

PROVIDER: S-EPMC3493535 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature