The impact of disulfiram treatment on the reinforcing effects of cocaine: a randomized clinical trial.

ABSTRACT:

Background

Clinical trials indicate that disulfiram (250 mg/d) reduces cocaine use, though one study found that treatment with lower doses of disulfiram (62.5 and 125 mg/d) increased cocaine use. We conducted the present study to better understand how disulfiram alters the reinforcing effects of cocaine in cocaine users.

Methods

Seventeen non-treatment seeking, cocaine-dependent volunteers participated in this double-blind, placebo-controlled, laboratory-based study. A cross-over design was utilized in which participants received placebo in one phase and disulfiram (250 mg/d) in the other. Following three days of study medication participants completed two choice sessions. In one they made 10 choices between receiving an intravenous infusion of saline or money that increased

SUBMITTER: Haile CN 

PROVIDER: S-EPMC3493584 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature