Structural and binding properties of two paralogous fatty acid binding proteins of Taenia solium metacestode.

ABSTRACT:

Background

Fatty acid (FA) binding proteins (FABPs) of helminths are implicated in acquisition and utilization of host-derived hydrophobic substances, as well as in signaling and cellular interactions. We previously demonstrated that secretory hydrophobic ligand binding proteins (HLBPs) of Taenia solium metacestode (TsM), a causative agent of neurocysticercosis (NC), shuttle FAs in the surrounding host tissues and inwardly transport the FAs across the parasite syncytial membrane. However, the protein molecules responsible for the intracellular trafficking and assimilation of FAs have remained elusive.

Methodology/principal findings

We isolated two novel TsMFABP genes (TsMFABP1 and TsMFABP2), which encoded 133- and 136-amino acid polypeptides with predicted molecular masses o

SUBMITTER: Kim SH 

PROVIDER: S-EPMC3493614 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature