Use of varenicline for smoking cessation and risk of serious cardiovascular events: nationwide cohort study.

ABSTRACT:

Objective

To investigate whether varenicline is associated with an increased risk of serious cardiovascular events compared with another drug used for smoking cessation, bupropion.

Design

Nationwide historical cohort study.

Setting

Denmark, 2007-10.

Participants

New users of varenicline (n = 17,926) and bupropion (n = 17,926).

Main outcome measures

Individual level data on dispensed drug prescriptions, cardiovascular events, and potential confounders were linked between registries. Cox regression was used to estimate hazard ratios of cardiovascular events in analyses matched for propensity score. The primary outcomes at six months after start of treatment were acute coronary syndrome, ischaemic stroke, and cardiovascular death analysed individually and a

SUBMITTER: Svanstrom H 

PROVIDER: S-EPMC3493624 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature