Fine-mapping of IL16 gene and prostate cancer risk in African Americans.

ABSTRACT:

Background

Prostate cancer is the most common type of cancer among men in the United States, and its incidence and mortality rates are disproportionate among ethnic groups. Although genome-wide association studies of European descents have identified candidate loci associated with prostate cancer risk, including a variant in IL16, replication studies in African Americans (AA) have been inconsistent. Here we explore single-nucleotide polymorphism (SNP) variation in IL16 in AAs and test for association with prostate cancer.

Methods

Association tests were conducted for 2,257 genotyped and imputed SNPs spanning IL16 in 605 AA prostate cancer cases and controls from Washington, D.C. Eleven of them were also genotyped in a replication population of 1,093 AAs from Chicago. We teste

SUBMITTER: Batai K 

PROVIDER: S-EPMC3493680 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature