Patterns of bone sarcomas as a second malignancy in relation to radiotherapy in adulthood and histologic type.

ABSTRACT:

Background

Radiotherapy decreases cancer mortality, but is associated with an increased incidence of second primary cancers, including osteosarcomas, especially after exposure in childhood. It remains uncertain whether radiation is related to other histologic types of bone sarcomas such as chondrosarcomas that are more common in adulthood.

Methods

Using data from 1973 to 2008 Surveillance Epidemiology and End Results registries, we evaluated long-term risk of bone cancer in 1,284,537 adult 5-year cancer survivors. We used standardized incidence ratios (SIR) to compare second bone sarcoma rates to the general population for each histologic type. We also used multivariate Poisson regression to estimate the relative risk (RR) associated with radiotherapy for the most common sub

SUBMITTER: Wu LC 

PROVIDER: S-EPMC3493823 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature