Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication.

ABSTRACT: Advances in genome technology have facilitated a new understanding of the historical and genetic processes crucial to rapid phenotypic evolution under domestication. To understand the process of dog diversification better, we conducted an extensive genome-wide survey of more than 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf. Here we show that dog breeds share a higher proportion of multi-locus haplotypes unique to grey wolves from the Middle East, indicating that they are a dominant source of genetic diversity for dogs rather than wolves from east Asia, as suggested by mitochondrial DNA sequence data. Furthermore, we find a surprising correspondence between genetic and phenotypic/functional breed groupings but there are exceptions that suggest phe

SUBMITTER: Vonholdt BM 

PROVIDER: S-EPMC3494089 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature