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A selenium analogue of firefly D-luciferin with red-shifted bioluminescence emission.

ABSTRACT: A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600 nm and is suitable for bioluminescence imaging studies in living subjects.

SUBMITTER: Conley NR 

PROVIDER: S-EPMC3494413 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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A selenium analogue of firefly D-luciferin with red-shifted bioluminescence emission.

Conley Nicholas R NR   Dragulescu-Andrasi Anca A   Rao Jianghong J   Moerner W E WE  

Angewandte Chemie (International ed. in English) 20120217 14

A selenium analogue of amino-D-luciferin, aminoseleno-D-luciferin, is synthesized and shown to be a competent substrate for the firefly luciferase enzyme. It has a red-shifted bioluminescence emission maximum at 600 nm and is suitable for bioluminescence imaging studies in living subjects. ...[more]

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