Evolutionary constraints and expression analysis of gene duplications in Rhodobacter sphaeroides 2.4.1.

ABSTRACT:

Background

Gene duplication is a major force that contributes to the evolution of new metabolic functions in all organisms. Rhodobacter sphaeroides 2.4.1 is a bacterium that displays a wide degree of metabolic versatility and genome complexity and therefore is a fitting model for the study of gene duplications in bacteria. A comprehensive analysis of 234 duplicate gene-pairs in R. sphaeroides was performed using structural constraint and expression analysis.

Results

The results revealed that most gene-pairs in in-paralogs are maintained under negative selection (ω ≤  0.3), but the strength of selection differed among in-paralog gene-pairs. Although in-paralogs located on different replicons are maintained under purifying selection, the duplicated genes distributed between th

SUBMITTER: Peters AE 

PROVIDER: S-EPMC3494609 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature