Uncoupling stimulus specificity and glomerular position in the mouse olfactory system.

ABSTRACT: Sensory information is often mapped systematically in the brain with neighboring neurons responding to similar stimulus features. The olfactory system represents chemical information as spatial and temporal activity patterns across glomeruli in the olfactory bulb. However, the degree to which chemical features are mapped systematically in the glomerular array has remained controversial. Here, we test the hypothesis that the dual roles of odorant receptors, in axon guidance and odor detection, can serve as a mechanism to map olfactory inputs with respect to their function. We compared the relationship between response specificity and glomerular position in genetically-defined olfactory sensory neurons expressing variant odorant receptors. We find that sensory neurons with the same odor resp

SUBMITTER: Zhang J 

PROVIDER: S-EPMC3494770 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature