The interleukin-23/interleukin-17 axis in spondyloarthritis.

ABSTRACT:

Purpose of review

To inform readers of recent advances in our understanding of the development and function of Th17 T cells and emerging data suggesting that the interleukin-23/interleukin-17 axis may be involved in the pathogenesis of spondyloarthritis.

Recent findings

The discovery of CD4+ Th17 T cells and the interleukin-23/interleukin-17 axis has challenged existing paradigms and the role of Th1 T cells in many autoimmune diseases. The development and cytokine profile of Th17 T cells differs in mice and humans. In humans, interleukin-23 synergizes with interleukin-6 and interleukin-1 to promote Th17 development. In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 produc

SUBMITTER: Layh-Schmitt G 

PROVIDER: S-EPMC3494971 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature