Association of ALOX5AP gene single nucleotide polymorphisms and cerebral infarction in the Han population of northern China.

ABSTRACT:

Background

To explore the association of ALOX5AP single nucleotide polymorphisms (SNPs) and haplotype with the occurrence of cerebral infarction in the Han population of northern China.

Methods

Blood samples were collected from 236 patients of Han ancestry with a history of cerebral infarction and 219 healthy subjects of Han ancestry with no history of cerebral infarction or cardiovascular disease. Applied Biosystems(®) TaqMan(®) SNP Genotyping Assays for SNP genotyping were used to determine the genotypes of 7 ALOX5AP SNP alleles (rs4073259, rs4769874, rs9315050, rs9551963, rs10507391, rs9579646, and rs4147064).

Results

One SNP allele (A) of rs4073259 was significantly associated with development of cerebral infarction (P = 0.049). In comparison to control groups, ha

SUBMITTER: Zhang SY 

PROVIDER: S-EPMC3495050 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature