Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families.

ABSTRACT:

Background

Genetic variants are likely to contribute to a portion of prostate cancer risk. Full elucidation of the genetic etiology of prostate cancer is difficult because of incomplete penetrance and genetic and phenotypic heterogeneity. Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive.

Methods

Parametric and non-parametric linkage analyses were performed using 26 microsatellite markers in each of 11 groups of multiple-case prostate cancer families from the International Consortium for Prostate Cancer Genetics (ICPCG). Meta-analyses of the resultant family-specific linkage statistics across the entire 1,323 families and in several predefined su

SUBMITTER: Bailey-Wilson JE 

PROVIDER: S-EPMC3495053 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature