Effect of postnatal intermittent hypoxia on growth and cardiovascular regulation of rat pups.

ABSTRACT:

Background

Intermittent hypoxic episodes are common among preterm infants, although longer term consequences on growth pattern and cardiovascular regulation are unclear. Furthermore, the effects of intermittent hypoxia (IH) may depend on the pattern of hypoxia-reoxygenation.

Objectives

We tested the hypothesis that a clustered versus dispersed pattern of repetitive IH during early postnatal life would induce differential long-term alteration in growth and cardiovascular regulation.

Methods

Sprague-Dawley rat pups were exposed to room air or to one of two patterns of IH (clustered vs. dispersed) from 1 to 7 days of life. Body weight was measured daily for the first 8 days and weekly from weeks 2 to 8. Blood pressure (BP) and heart rate were measured weekly from weeks 4

SUBMITTER: Pozo ME 

PROVIDER: S-EPMC3495107 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature