The role of statin therapy in the prevention of atrial fibrillation: a meta-analysis of randomized controlled trials.

ABSTRACT:

What is already known about this subject

Atrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia, and AF is associated with relatively higher all-cause mortality in both men and women. However, there are limited treatment options for AF. Statins are hypothesized to have a benefit against arrhythmias in addition to well-established secondary prevention benefit for atherosclerotic coronary artery disease, yet the data are inconsistent

What this study adds

Statin therapy was significantly associated with a decreased risk of incidence or recurrence of AF. The benefit of statin therapy seemed more markedly in secondary prevention than primary prevention. These results provided some evidence for the benefit of statins beyond their lipid-lowering activ

SUBMITTER: Fang WT 

PROVIDER: S-EPMC3495139 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature