Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility.

ABSTRACT:

Background

The genetic mechanisms underlying asthma remain unclear. Increased permeability of the microvasculature is a feature of asthma, and the sphingosine-1-phosphate receptor (S1PR1) is an essential participant regulating lung vascular integrity and responses to lung inflammation.

Objective

We explored the contribution of polymorphisms in the S1PR1 gene to asthma susceptibility.

Methods

A combination of gene resequencing for single nucleotide polymorphism (SNP) discovery, case-control association, functional evaluation of associated SNPs, and protein immunochemistry studies was used.

Results

Immunohistochemistry studies demonstrated significantly decreased S1PR1 protein expression in pulmonary vessels in lungs of asthmatic patients compared with those of n

SUBMITTER: Sun X 

PROVIDER: S-EPMC3495167 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature