Serum C-reactive protein and risk of pancreatic cancer in two nested, case-control studies.

ABSTRACT:

Background

Many epidemiologic studies have examined the association between C-reactive protein (CRP) and risk of cancer with inconsistent results.

Methods

We conducted two nested, case-control studies in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) to test whether prediagnostic circulating CRP concentrations were associated with pancreatic adenocarcinoma. Between 1985 and 2004, 311 cases occurred in ATBC and between 1994 and 2006, 182 cases occurred in PLCO. Controls (n = 510 in ATBC, n = 374 in PLCO) were alive at the time the case was diagnosed and were matched by age, date of blood draw, sex, and race. We used conditional logistic regression adjusted for smoking to calculate OR

SUBMITTER: Douglas JB 

PROVIDER: S-EPMC3495286 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature