Histone modification pattern evolution after yeast gene duplication.

ABSTRACT:

Background

Gene duplication and subsequent functional divergence especially expression divergence have been widely considered as main sources for evolutionary innovations. Many studies evidenced that genetic regulatory network evolved rapidly shortly after gene duplication, thus leading to accelerated expression divergence and diversification. However, little is known whether epigenetic factors have mediated the evolution of expression regulation since gene duplication. In this study, we conducted detailed analyses on yeast histone modification (HM), the major epigenetics type in this organism, as well as other available functional genomics data to address this issue.

Results

Duplicate genes, on average, share more common HM-code patterns than random singleton pairs in their

SUBMITTER: Zou Y 

PROVIDER: S-EPMC3495647 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature