GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.

ABSTRACT:

Background

Although many diseases have been well characterized at the molecular level, the underlying mechanisms are often unknown. Nearly half of all human genes remain poorly studied, yet these genes may contribute to a number of disease processes. Genes involved in common biological processes and diseases are often co-expressed. Using known disease-associated genes in a co-expression analysis may help identify and prioritize novel candidate genes for further study.

Results

We have created an online tool, called GeneFriends, which identifies co-expressed genes in over 1,000 mouse microarray datasets. GeneFriends can be used to assign putative functions to poorly studied genes. Using a seed list of disease-associated genes and a guilt-by-association method, GeneFriends allo

SUBMITTER: van Dam S 

PROVIDER: S-EPMC3495651 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature