Switching industrial production processes from complex to defined media: method development and case study using the example of Penicillium chrysogenum.

ABSTRACT:

Background

Filamentous fungi are versatile cell factories and widely used for the production of antibiotics, organic acids, enzymes and other industrially relevant compounds at large scale. As a fact, industrial production processes employing filamentous fungi are commonly based on complex raw materials. However, considerable lot-to-lot variability of complex media ingredients not only demands for exhaustive incoming components inspection and quality control, but unavoidably affects process stability and performance. Thus, switching bioprocesses from complex to defined media is highly desirable.

Results

This study presents a strategy for strain characterization of filamentous fungi on partly complex media using redundant mass balancing techniques. Applying the suggested meth

SUBMITTER: Posch AE 

PROVIDER: S-EPMC3495681 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature