Nonpathogenic Lactobacillus rhamnosus activates the inflammasome and antiviral responses in human macrophages.

ABSTRACT: In this study, we have utilized global gene expression profiling to compare the responses of human primary macrophages to two closely related, well-characterized Lactobacillus rhamnosus strains GG and LC705, since our understanding of the responses elicited by nonpathogenic bacteria in human innate immune system is limited. Macrophages are phagocytic cells of the innate immune system that perform sentinel functions to initiate appropriate responses to surrounding stimuli. Macrophages that reside on gut mucosa encounter ingested and intestinal bacteria. Bacteria of Lactobacillus genus are nonpathogenic and used in food and as supplements with health-promoting probiotic potential. Our results demonstrate that live GG and LC705 induced quantitatively different gene expression profiles in macr

SUBMITTER: Miettinen M 

PROVIDER: S-EPMC3495788 | biostudies-literature | 2012 Nov-Dec

REPOSITORIES: biostudies-literature