Lactic acid production by Streptococcus thermophilus alters Clostridium difficile infection and in vitro Toxin A production.

ABSTRACT: Antibiotic treatment to treat specific infections has the potential to effectively target the offending microbe as well as other microbes that colonize sites within a host. Antibiotic-associated diarrhea (AAD) is a classic example resulting from disruption of host microbial communities; 20% of patients with AAD are likely to become colonized with Clostridium difficile. Restoration of a "normal" microbial community within the host using probiotic bacteria is one approach to circumvent AAD and C. difficile infection. The goals of this study were to assess the interactions between Streptococcus thermophilus, a potential probiotic organism and C. difficile using both in vitro and in vivo systems. Exposure of C. difficile to filtered supernatants from S. thermophilus showed a dose-dependent, ba

SUBMITTER: Kolling GL 

PROVIDER: S-EPMC3495789 | biostudies-literature | 2012 Nov-Dec

REPOSITORIES: biostudies-literature